Output from the UK industries fell 0.7% in November, compared with October, the biggest monthly drop since the start of 2013.
However, compared with November 2014, output grew by 0.9%. And the Office for National Statistics (ONS), which released the data, urged caution over the monthly comparison, stressing that monthly figures can often be volatile.
Manufacturing was the biggest contributor to the decline, decreasing 0.4%. The ONS said the pharmaceuticals industry made the biggest shrinking contribution.
Looking at the three months to November, industrial output was up 0.2%, with manufacturing up 0.5%.
Mark Stephenson, UK manufacturing industry leader at Deloitte, said: "November's manufacturing output highlights the difficulties UK manufacturers continue to face. The pound remains relatively strong, particularly when compared to the euro. This makes for very tough exporting conditions to the UK's largest single market for manufactured goods."