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Two hundred of the UK's leading entrepreneurs have warned that leaving the European Union "is not worth the risk".

The open letter, published by the Financial Times, includes signatures of the leaders of some of Britain's most entrepreneurial businesses, both big and small, and several of which are named on the Smith & Williamson Power 100.

While admitting that the EU "isn't perfect", the group wrote: "Once the latest round of British-backed EU reforms have been completed, the European market for services, as well as digital products, will create even greater business opportunities for our companies."

The entrepreneurs stress that leaving the Union could lead to "lost investment, missed opportunities and lost jobs".

"The UK is currently the best place in Europe to launch and grow a business; leaving the EU will undoubtedly undermine the ability of Britain’s entrepreneurs to start-up, innovate, and grow. It is simply not worth the risk," it added.

Among those to sign the letter are Alastair Lukies CBE - chairman of Innovate Finance and member of the Smith & Williamson Power 100, Alex Chesterman - founder and CEO of Zoopla, Bindi Karia - a member of the Tech London Advocates Advisory Board, Brent Hoberman - co-founder of Founders Factory and lastminute.com, Darren Westlake - CEO of Crowdcube and member of the Smith & Williamson Power 100, Debbie Woskow - chair of Sharing Economy UK, Doug Monro - co-founder and CEO of Adzuna, Edward Wray - co-founder of Betway, Eileen Burbidge - partner at Passion Capital and member of the Smith & Williamson Power 100, Jacqueline Gold - CEO of Ann Summers, Julie Deane OBE - founder and CEO of Cambridge Satchel Co. and Great British Entrepreneur of the Year 2013.